MDCO-700, a New Generation Anesthetic: Evaluation of Two Formulations in Sprague-Dawley Rats
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چکیده
منابع مشابه
Subchronic Hepatotoxicity Evaluation of 2,3,4,6-Tetrachlorophenol in Sprague Dawley Rats
Male Sprague Dawley rats were exposed to 2,3,4,6-tetrachlorophenol (TCP) for 5 days, 2 weeks, 4 weeks, or 13 weeks. TCP was administered by gavage at doses of 0, 10, 25, 50, 100, or 200 mg/kg/day. Endpoints evaluated included clinical observations, body weights, liver weights, serum chemistry, blood TCP, gross pathology, and liver histopathology. There were no TCP exposure-related clinical sign...
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Among organophosphorus pesticides, malathion is considered a relatively safe compound. Malathion, however, functions by inhibiting cholinesterase (ChE) enzymes of the nervous system in both vertebrate and invertebrate organisms. The inactivation of ChE by malathion is therefore a useful indicator of exposure. Because of the increased application of these pesticides, their entry into various env...
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Timed-pregnant Sprague-Dawley (CD) outbred rats and New Zealand White rabbits were dosed by gavage with methacrylonitrile (MACR) in distilled water during major organogenesis. Rats were dosed on Gestational Days (GD) 6 through 15 (0, 5, 25, or 50 mg MACR/kg/day) and rabbits on GD 6 through 19 (0, 1, 3, or 5 mg MACR/kg/day). Maternal clinical status was monitored daily during treatment. At termi...
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BACKGROUND Nutraceuticals help in combating some of the major health problems of the century including cancer, and 'nutraceutical formulations' have led to the new era of medicine and health. OBJECTIVE To develop different nutraceutical formulations and to assess the anticancer potential of nutraceutical formulations in N-methyl-N-nitrosourea (MNU)-induced mammary cancer in Sprague Dawley rat...
متن کاملAnesthetic and pathological changes following high doses of ketamine and xylazine in Sprague Dawley rats
The main objective of this study was to compare the effects of ketamine and xylazine in aging rats when coadministered intraperitoneally at high anesthetic doses. Three groups (n=6 rats/group) consisting of rats at 3, 6 and 12 months of age were used. During anesthesia, animals were monitored for heart rate, respiratory frequency, blood oxygen saturation, and rectal temperature. The corneal and...
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ژورنال
عنوان ژورنال: SOJ Anesthesiology & Pain Management
سال: 2018
ISSN: 2374-684X
DOI: 10.15226/2374-684x/5/1/00156